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Последна промяна: 25.01.2009 00:14
Тинктурата от котешка стъпка би била най-ефикасна при третиране на суровата билка в чист алкохол и последващото му разреждане и изпаряване.
Надявам се популярна статия като тази да не допринесе за драстичното и спекулативно нарастване на цената на изсушената дрога, тъй като при нея, ефективността е близка до плацебото.
In vitro screening for antitumour activity of Clinopodium vulgare L. (Lamiaceae) extracts. Dzhambazov B, Daskalova S, Monteva A, Popov N.
Section for Medical Inflammation Research, Department of Cell and Molecular Biology, Lund University, Sweden. Balik.Dzhambazov@inflam.lu.se
Aqueous extract of Clinopodium vulgare L. showed strong antitumour activity when tested in vitro on A2058 (human metastatic melanoma), HEp-2 (epidermoid carcinoma, larynx, human) and L5178Y (mouse lymphoma) cell lines-6 h after treatment disintegration of the nuclei and cell lysis started. Applied at a concentration of 80 microg/ml it reduced the cell survival to 1.0, 5.6 and 6.6%, respectively. The concentrations of aqueous extract inhibiting the growth of A2058, HEp-2 and L5178Y cells by 50% (IC50 values) were calculated to be 20, 10 and 17.8 microg/ml respectively. Two groups of active substances were detected: the first one, probably combining glycosides, influenced adhesion, while the second one caused massive cell vacuolisation. The chloroform extract, which contained ursolic acid and gentriacontan had also cytotoxic, however a little bit weaker effect. All changes observed were irreversible.
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